Zoloft (sertraline) is good for treating depression and anxiety, but it can interact with many medicines.
- One of the more effective and better tolerated antidepressants in its class.
- Causes less sleepiness than other antidepressants.
- Available as a generic, which is cheaper.
- Best choice among antidepressants if you are pregnant.
- Takes at least 1 to 2 weeks to kick in and can take up to 12 weeks for maximum effect.
- Can cause low sex drive, an inability to orgasm or ejaculate, and minor weight gain (1 to 5 pounds).
- Is more likely to cause diarrhea compared to other antidepressants.
- Interacts with lots of other medicines.
- You may need to try out several different antidepressants before you find the one that works for you.
Zoloft (sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It raises serotonin levels in the brain, which affects mood.
- Drug class: Mental health
- Rx status: Prescription only
- Generic status: Lower-cost generic available (sertraline)